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Group C consisted of men that received NO steroid injections or tablets but would perform weight lifting and traditional bodybuilding exercises and workouts, as per the protocol prescribed by the study ( Table2 ). In order to evaluate the effect of TAA alone on muscle loss, we first determined body composition before and after TAA supplementation, and then measured muscle loss as a percentage of baseline strength ( Figure 2 ). In all participants, the initial body composition measured before the study and following supplementation was markedly greater than that of lean or obese subjects ( Table 2 ). These changes indicated that, in comparison to lean subjects, the addition of TAA to the normal-weight subjects provided an additive effect to that of the NO testosterone treatment. The weight-lifting protocol used in the current study was previously described , . While the exercises selected for the current study were similar to those described in the previous study ( Table 2 ), we did observe a significant reduction in the absolute weights used, with some exercises being used at 30% more than was used in the previous study. Although absolute increases were observed on the L-sit, side plank, and bench press, the improvements were not significant enough to be considered statistically significant, nor were those reductions statistically significant. As the absolute weights in the resistance-training sets were not used, changes in the relative weights at which each exercise was used were assessed with a paired t test. The decrease in absolute weight sets from the baseline was statistically significant: the L-sit increased by 21.2 mm during the first 8 weeks, but did not reach statistically significant difference with the bench press at the final 8 weeks ( t = 0.17, P = 0.07). In addition, after the 8 weeks in which the training loads were decreased by 28% compared to baseline and after the 8 weeks in which weights were reduced by 10% compared to baseline, the absolute weights used in the resistance-training sets were similar ( t = 0.14, P = 0.04). The total number of total training weeks did not differ between the groups during the 8 weeks of this study ( Figure 1 ). There were no differences in the number of total training weeks in the two groups at any time point ( Table 2 ). Discussion The main finding in our study is that TAA supplementation is effective in reducing muscle hypertrophy and strength in healthy adult males. The changes in muscle mass seen after supplementation are clinically relevant in this population; however, changes in lean body weight and percent body fat did not change significantly. The strength increases during the first eight weeks after TAA supplementation were significant and clinically meaningful given the current standard of care Related Article: